![]() For them, EST hits the spot ( ScienceNOW, ). Heterosexual men, on the other hand, don't respond to AND. In response to a whiff of AND, heterosexual women and homosexual men respond in the same way: The front part of their brain's hypothalamus, which plays a role in sexual behavior, starts to rev up. Nevertheless, the compounds do seem to have sex-specific effects. But neither has yet met the strict criteria that would define it as a pheromone. Potential candidates include AND, a progesterone-derived molecule found in men's sweat, and EST, which is related to estrogen and found in pregnant women's urine. Whether the substances also play a role in human mating is less clear. The pheromones of female moths, for example, can attract a mate from several kilometers away. Many animals use the sex-specific scents to sniff out their partner of choice. Pheromones are the ultimate aphrodisiacs. The findings could lead to new insights into the neural basis of sexual preference and behavior, say the researchers. When it comes to responding to pheromonelike chemical signals, lesbian women are much more like heterosexual men than their straight counterparts, according to a new study.
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